Assay Detail
Functional
CHEMBL5053605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell differentiation in human THP-1 cells assessed as CD14 expression after 3 days by flow cytometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-<i>a</i>]pyridine Scaffold: SAR of the Biphenyl Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.50 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5077508 | — | — | 1 | 8.62 |
| CHEMBL5090281 | — | — | 1 | 7.76 |
| CHEMBL5084878 | — | — | 1 | 7.51 |
| CHEMBL5090431 | — | — | 1 | 7.50 |
| CHEMBL5078949 | — | — | 1 | 7.42 |
| CHEMBL4173846 | — | — | 1 | 7.40 |
| CHEMBL5092556 | — | — | 1 | 7.17 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5077508 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5090281 | — | EC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5084878 | — | EC50 | = | 31.2 | nM | 7.51 |
| CHEMBL5090431 | — | EC50 | = | 31.5 | nM | 7.50 |
| CHEMBL5078949 | — | EC50 | = | 38.3 | nM | 7.42 |
| CHEMBL4173846 | — | EC50 | = | 39.7 | nM | 7.40 |
| CHEMBL5092556 | — | EC50 | = | 67.6 | nM | 7.17 |
| CHEMBL38434 | BREQUINAR | EC50 | = | 248.6 | nM | 6.60 |