Assay Detail
Binding
CHEMBL5054564
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Inhibition of PD-1/PDL1 protein-protein interaction (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.30 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071326 | — | — | 1 | 8.85 |
| CHEMBL5092074 | — | — | 1 | 7.75 |
| CHEMBL4848279 | — | — | 1 | - |
| CHEMBL5094119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071326 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5092074 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4848279 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5094119 | — | IC50 | <= | 10.0 | nM | - |