Assay Detail
Functional
CHEMBL5055474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5079947 | — | — | 1 | 7.70 |
| CHEMBL5076703 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5079947 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5076703 | — | IC50 | = | 20.0 | nM | 7.70 |