Assay Detail
Functional
CHEMBL5055732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antinociceptive activity in po dosed FVB hNav1.7 transgenic mouse model of inherited erythromelalgia harboring I848T mutation assessed as reduction in number of nociceptive aconitine injected after compound administration
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Acyl-sulfonamide Na<sub>v</sub>1.7 Inhibitors GDC-0276 and GDC-0310.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.87 | 5.96 |
| fEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094715 | — | — | 2 | 5.96 |
| CHEMBL3657855 | — | — | 2 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094715 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3657855 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3657855 | — | fEC50 | = | 0.42 | nM | - |
| CHEMBL5094715 | — | fEC50 | = | 3.5 | nM | - |