Assay Detail
Functional
CHEMBL5055816
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Antiinflammatory activity against human THP-1 cells assessed as reduction in LPS and BzATP-induced IL-1beta release measured after 50 mins by microplate reader
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.42 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1628690 | — | — | 1 | 7.82 |
| CHEMBL3952549 | — | — | 1 | 7.57 |
| CHEMBL5086274 | — | — | 1 | 7.42 |
| CHEMBL437703 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1628690 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3952549 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5086274 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL437703 | — | IC50 | = | 140.0 | nM | 6.85 |