Assay Detail
Binding
CHEMBL5056986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubated for 72 hrs followed by substrate addition measured after 24 hrs by alkaline phosphatase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.05 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 9.74 |
| CHEMBL2104744 | NORGESTOMET | 2.0 | 1 | 8.35 |
| CHEMBL5077912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL2104744 | NORGESTOMET | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5077912 | — | EC50 | > | 125.0 | nM | - |