Compound Detail
CHEMBL2104744
NORGESTOMET 🧪 Phase II
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🧪 Phase II
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3[C@@H](C)C[C@@]21C
Basic Information
| ChEMBL ID | CHEMBL2104744 |
| Name | NORGESTOMET |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IWSXBCZCPVUWHT-VIFKTUCRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
2
Known Names
Molecular Properties
372.5
MW (Da)
4.27
ALogP
4
HBA
0
HBD
60.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
EC50 1 meas. best 8.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | EC50 | 8.35 | 8.35 | 4.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | EC50 | = | 4.5 | nM | 8.35 | Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as subs... | 34607200 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34607200 | 10.1016/j.bmc.2021.116425 | Progesterone receptor | 3 |
Data from ChEMBL 36 via Core Engine