Assay Detail
Binding
CHEMBL5058468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NADH measured after 10 mins by HPLC method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Placenta |
| Subcellular | Cytosol |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.91 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089787 | — | — | 1 | 8.57 |
| CHEMBL5090458 | — | — | 1 | 8.54 |
| CHEMBL5080299 | — | — | 1 | 8.25 |
| CHEMBL5076534 | — | — | 1 | 8.09 |
| CHEMBL5078630 | — | — | 1 | 7.94 |
| CHEMBL5087553 | — | — | 1 | 7.75 |
| CHEMBL5089172 | — | — | 1 | 7.65 |
| CHEMBL5084876 | — | — | 1 | 7.51 |
| CHEMBL5074435 | — | — | 1 | 7.50 |
| CHEMBL5093589 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089787 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5090458 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5080299 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5076534 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5078630 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5087553 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5089172 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL5084876 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5074435 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL5093589 | — | IC50 | = | 55.2 | nM | 7.26 |