Assay Detail
Functional
CHEMBL5096261
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Antiproliferative activity against human SNU-16 cells overexpressing FGFR2 assessed as inhibition of cell proliferative by measuring ATP level after 72 hrs by luminescence based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.62 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205436 | — | — | 1 | 7.37 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 7.19 |
| CHEMBL5189958 | — | — | 1 | 7.18 |
| CHEMBL5177815 | — | — | 1 | 7.15 |
| CHEMBL5191338 | — | — | 1 | 7.13 |
| CHEMBL5199374 | — | — | 1 | 7.07 |
| CHEMBL5174735 | — | — | 1 | 6.92 |
| CHEMBL5183691 | — | — | 1 | 6.88 |
| CHEMBL5207255 | — | — | 1 | 6.82 |
| CHEMBL5192921 | — | — | 1 | 6.71 |
| CHEMBL5183603 | — | — | 1 | 6.71 |
| CHEMBL5171314 | — | — | 1 | 6.68 |
| CHEMBL5173892 | — | — | 1 | 6.65 |
| CHEMBL5179660 | — | — | 1 | 6.59 |
| CHEMBL5180534 | — | — | 1 | 6.49 |
| CHEMBL5191301 | — | — | 1 | 6.47 |
| CHEMBL5196797 | — | — | 1 | 6.46 |
| CHEMBL5182544 | — | — | 1 | 6.45 |
| CHEMBL5209158 | — | — | 1 | 6.45 |
| CHEMBL5186357 | — | — | 1 | 6.21 |
| CHEMBL5195888 | — | — | 1 | 6.08 |
| CHEMBL5181778 | — | — | 1 | 6.04 |
| CHEMBL5183701 | — | — | 1 | 6.01 |
| CHEMBL5182130 | — | — | 1 | 5.92 |
| CHEMBL5201819 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205436 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5189958 | — | IC50 | = | 65.32 | nM | 7.18 |
| CHEMBL5177815 | — | IC50 | = | 71.42 | nM | 7.15 |
| CHEMBL5191338 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5199374 | — | IC50 | = | 85.64 | nM | 7.07 |
| CHEMBL5174735 | — | IC50 | = | 120.7 | nM | 6.92 |
| CHEMBL5183691 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL5207255 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5192921 | — | IC50 | = | 194.5 | nM | 6.71 |
| CHEMBL5183603 | — | IC50 | = | 196.2 | nM | 6.71 |
| CHEMBL5171314 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL5173892 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL5179660 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL5180534 | — | IC50 | = | 324.9 | nM | 6.49 |
| CHEMBL5191301 | — | IC50 | = | 336.3 | nM | 6.47 |
| CHEMBL5196797 | — | IC50 | = | 347.6 | nM | 6.46 |
| CHEMBL5182544 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL5209158 | — | IC50 | = | 354.9 | nM | 6.45 |
| CHEMBL5186357 | — | IC50 | = | 623.5 | nM | 6.21 |
| CHEMBL5195888 | — | IC50 | = | 837.0 | nM | 6.08 |
| CHEMBL5181778 | — | IC50 | = | 903.4 | nM | 6.04 |
| CHEMBL5183701 | — | IC50 | = | 981.6 | nM | 6.01 |
| CHEMBL5182130 | — | IC50 | = | 1206.0 | nM | 5.92 |
| CHEMBL5201819 | — | IC50 | = | 1285.0 | nM | 5.89 |