Compound Detail
CHEMBL5209158
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1cc(CCc2cc(-c3nc4ccc(-c5ccc(N6CCOCC6)nc5)cc4[nH]3)n[nH]2)cc(OC)c1
Basic Information
| ChEMBL ID | CHEMBL5209158 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FACLICQSXLCKBZ-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
510.6
MW (Da)
4.65
ALogP
7
HBA
2
HBD
101.2
PSA (Ų)
0.31
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.07 | 8.07 | 8.5 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.86 | 6.86 | 139.1 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 6.7 | 6.7 | 198.0 | 1 |
| SNU-16 CHEMBL613529 | IC50 | 6.45 | 6.45 | 354.9 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.7 | 5.7 | 1990.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 8.5 | nM | 8.07 | Inhibition of recombinant N-terminal GST-tagged human FGFR2 (399 to 821 residues... | 33199155 |
| Fibroblast growth factor receptor 1 | IC50 | = | 139.1 | nM | 6.86 | Inhibition of recombinant N-terminal GST-tagged human FGFR1 (398 to 822 residues... | 33199155 |
| Fibroblast growth factor receptor 3 | IC50 | = | 198.0 | nM | 6.7 | Inhibition of recombinant human N-terminal GST-tagged FGFR3 (436 to 806 residues... | 33199155 |
| SNU-16 | IC50 | = | 354.9 | nM | 6.45 | Antiproliferative activity against human SNU-16 cells overexpressing FGFR2 asses... | 33199155 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1990.0 | nM | 5.7 | Inhibition of recombinant N-terminal GST-tagged human KDR (790 to 1356 residues)... | 33199155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33199155 | 10.1016/j.ejmech.2020.112990 | Fibroblast growth factor receptor 1 | 1 |
| 33199155 | 10.1016/j.ejmech.2020.112990 | Fibroblast growth factor receptor 2 | 1 |
| 33199155 | 10.1016/j.ejmech.2020.112990 | Fibroblast growth factor receptor 3 | 1 |
| 33199155 | 10.1016/j.ejmech.2020.112990 | Vascular endothelial growth factor receptor 2 | 1 |
| 33199155 | 10.1016/j.ejmech.2020.112990 | SNU-16 | 1 |
Data from ChEMBL 36 via Core Engine