Assay Detail
Binding
CHEMBL5097634
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Inhibition of MNK1 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Progress in developing MNK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.45 | 9.00 |
| IC5 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201681 | — | — | 1 | 9.00 |
| CHEMBL5174006 | — | — | 1 | 9.00 |
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 8.15 |
| CHEMBL3702341 | — | — | 1 | 7.64 |
| CHEMBL3354997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201681 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5174006 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3545307 | MERESTINIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3702341 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3354997 | — | IC5 | = | 6.0 | nM | - |