Compound Detail
CHEMBL5174006
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Basic Information
| ChEMBL ID | CHEMBL5174006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RWXFMIUPGZFSPK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
331.3
MW (Da)
2.75
ALogP
6
HBA
3
HBD
95.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 1 CHEMBL4718 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of MNK1 (unknown origin) | 33892273 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33892273 | 10.1016/j.ejmech.2021.113420 | MAP kinase-interacting serine/threonine-protein kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine