Assay Detail
Functional
CHEMBL5098053
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Antiviral activity against HIV 1 infected in human HeLa-MAGI cells assessed as inhibition of viral replication measured 24 hrs post infection by fluorescence based analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa-MAGI |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.22 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.28 |
| CHEMBL5185855 | — | — | 1 | 5.76 |
| CHEMBL5198310 | — | — | 1 | 5.60 |
| CHEMBL5207685 | — | — | 1 | 5.54 |
| CHEMBL5176128 | — | — | 1 | 5.27 |
| CHEMBL5173288 | — | — | 1 | 5.08 |
| CHEMBL5183730 | — | — | 1 | 4.95 |
| CHEMBL5188823 | — | — | 1 | 4.93 |
| CHEMBL5197780 | — | — | 1 | 4.88 |
| CHEMBL5191403 | — | — | 1 | 4.84 |
| CHEMBL5198940 | — | — | 1 | 4.79 |
| CHEMBL5182942 | — | — | 1 | 4.75 |
| CHEMBL5202973 | — | — | 1 | - |
| CHEMBL5207303 | — | — | 1 | - |
| CHEMBL5194402 | — | — | 1 | - |
| CHEMBL5187082 | — | — | 1 | - |
| CHEMBL5174596 | — | — | 1 | - |
| CHEMBL5172754 | — | — | 1 | - |
| CHEMBL5191482 | — | — | 1 | - |
| CHEMBL5184868 | — | — | 1 | - |
| CHEMBL5172266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5185855 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5198310 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5207685 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5176128 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5173288 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5183730 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5188823 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5197780 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5191403 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL5198940 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5182942 | — | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL5202973 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5207303 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5194402 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5187082 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5174596 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5172754 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5191482 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5184868 | — | EC50 | > | 16000.0 | nM | - |
| CHEMBL5172266 | — | EC50 | > | 50000.0 | nM | - |