Assay Detail
Binding
CHEMBL5109092
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Inhibition of cGAS in human THP-1 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecules targeting cGAS-STING pathway for autoimmune disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.36 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174318 | — | — | 1 | 5.77 |
| CHEMBL4448176 | — | — | 1 | 5.71 |
| CHEMBL5081956 | — | — | 1 | 5.53 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.16 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174318 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4448176 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5081956 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | IC50 | = | 23000.0 | nM | 4.64 |