Assay Detail
Binding
CHEMBL5109147
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Binding affinity to FITC-labelled dsDNA (unknown origin) assessed as dissociation constant incubated for 10 mins by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
RpoN-Based stapled peptides with improved DNA binding suppress <i>Pseudomonas aeruginosa</i> virulence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.23 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183480 | — | — | 1 | 6.46 |
| CHEMBL5182279 | — | — | 1 | 6.44 |
| CHEMBL5175391 | — | — | 1 | 6.42 |
| CHEMBL5174777 | — | — | 1 | 6.42 |
| CHEMBL5173726 | — | — | 1 | 6.08 |
| CHEMBL5185120 | — | — | 1 | 6.02 |
| CHEMBL5170110 | — | — | 1 | 5.78 |
| CHEMBL5170635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183480 | — | Kd | = | 346.0 | nM | 6.46 |
| CHEMBL5182279 | — | Kd | = | 366.0 | nM | 6.44 |
| CHEMBL5175391 | — | Kd | = | 385.0 | nM | 6.42 |
| CHEMBL5174777 | — | Kd | = | 376.0 | nM | 6.42 |
| CHEMBL5173726 | — | Kd | = | 834.0 | nM | 6.08 |
| CHEMBL5185120 | — | Kd | = | 947.0 | nM | 6.02 |
| CHEMBL5170110 | — | Kd | = | 1680.0 | nM | 5.78 |
| CHEMBL5170635 | — | Kd | > | 20000000.0 | nM | - |