Assay Detail
Functional
CHEMBL5109592
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Antiinflammatory activity in LPS-stimulated mouse BV-2 cells assessed as inhibition of IL-1beta release at 10 uM and measured after 8 hrs by ELISA
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 2 | 7.39 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212418 | — | — | 1 | 8.47 |
| CHEMBL4215895 | — | — | 1 | 6.30 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL232211 | MINOZAC FREE BASE | 1.0 | 1 | - |
| CHEMBL5200916 | — | — | 1 | - |
| CHEMBL5190868 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212418 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4215895 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL6 | INDOMETHACIN | Inhibition | = | 34.9 | % | - |
| CHEMBL232211 | MINOZAC FREE BASE | Inhibition | = | 28.68 | % | - |
| CHEMBL5200916 | — | Inhibition | = | 44.3 | % | - |
| CHEMBL5190868 | — | Inhibition | = | 42.9 | % | - |