Assay Detail
Functional
CHEMBL5111974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human THP-1 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-<i>a</i>]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.44 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173846 | — | — | 1 | 7.14 |
| CHEMBL5192490 | — | — | 1 | 6.96 |
| CHEMBL5196292 | — | — | 1 | 6.64 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.58 |
| CHEMBL5209405 | — | — | 1 | 6.30 |
| CHEMBL4165815 | — | — | 1 | 5.87 |
| CHEMBL5183718 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173846 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5192490 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5196292 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL38434 | BREQUINAR | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL5209405 | — | EC50 | = | 499.0 | nM | 6.30 |
| CHEMBL4165815 | — | EC50 | = | 1344.0 | nM | 5.87 |
| CHEMBL5183718 | — | EC50 | = | 2646.0 | nM | 5.58 |