Assay Detail
Binding
CHEMBL5112293
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Inhibition of human recombinant CA5A assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.67 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL5206696 | — | — | 1 | 7.11 |
| CHEMBL5171860 | — | — | 1 | 7.11 |
| CHEMBL5198237 | — | — | 1 | 7.05 |
| CHEMBL5177166 | — | — | 1 | 7.03 |
| CHEMBL5193531 | — | — | 1 | 6.34 |
| CHEMBL5191973 | — | — | 1 | 6.18 |
| CHEMBL5205289 | — | — | 1 | 5.36 |
| CHEMBL5201114 | — | — | 1 | - |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | - |
| CHEMBL25554 | — | — | 1 | - |
| CHEMBL5191609 | — | — | 1 | - |
| CHEMBL5193118 | — | — | 1 | - |
| CHEMBL5184240 | — | — | 1 | - |
| CHEMBL5194237 | — | — | 1 | - |
| CHEMBL5203377 | — | — | 1 | - |
| CHEMBL5176469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL5206696 | — | Ki | = | 77.5 | nM | 7.11 |
| CHEMBL5171860 | — | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL5198237 | — | Ki | = | 89.6 | nM | 7.05 |
| CHEMBL5177166 | — | Ki | = | 94.1 | nM | 7.03 |
| CHEMBL5193531 | — | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL5191973 | — | Ki | = | 658.8 | nM | 6.18 |
| CHEMBL5205289 | — | Ki | = | 4346.0 | nM | 5.36 |
| CHEMBL5201114 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1422 | SITAGLIPTIN | Ki | > | 10000.0 | nM | - |
| CHEMBL25554 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5191609 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5193118 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5184240 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5194237 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5203377 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5176469 | — | Ki | > | 10000.0 | nM | - |