Assay Detail
Functional
CHEMBL5114052
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Antitrypanosomal activity against Trypanosoma brucei assessed as parasite growth inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.95 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322216 | — | — | 1 | 6.23 |
| CHEMBL2322213 | — | — | 1 | 6.06 |
| CHEMBL2322509 | — | — | 1 | 5.86 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322216 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL2322213 | — | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL2322509 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 2230.0 | nM | 5.65 |