Assay Detail
Functional
CHEMBL5114526
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Cytotoxicity against human RPMI 8402 cells assessed as cell growth inhibition measured after 4 days by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Topoisomerase I inhibitors: Challenges, progress and the road ahead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.38 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72772 | — | — | 1 | 8.70 |
| CHEMBL309355 | — | — | 1 | 8.52 |
| CHEMBL609965 | — | — | 1 | 7.75 |
| CHEMBL5196942 | — | — | 1 | 7.40 |
| CHEMBL5186082 | — | — | 1 | 7.16 |
| CHEMBL609455 | — | — | 1 | 7.12 |
| CHEMBL5178685 | — | — | 1 | 7.00 |
| CHEMBL5194864 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72772 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL309355 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL609965 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5196942 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5186082 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL609455 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5178685 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5194864 | — | IC50 | = | 4500.0 | nM | 5.35 |