Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5116796

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL233)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.
Zampieri D, Fortuna S, Romano M, Amata E, Dichiara M, Marrazzo A, Pasquinucci L, Turnaturi R, Mamolo MG.
Bioorg Med Chem Lett (2022) 72 : 128860 -128860
PubMed 35724925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.33 8.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38874 DAMGO 1 8.83
CHEMBL5187029 1 7.25
CHEMBL5207122 1 5.91
CHEMBL5169420 1 5.75
CHEMBL5201355 1 5.56
CHEMBL5182253 1 5.54
CHEMBL5186843 1 5.46
CHEMBL5206034 1 -
CHEMBL5201238 1 -
CHEMBL54 HALOPERIDOL 4.0 1 -
CHEMBL100116 PENTAZOCINE 4.0 1 -
CHEMBL282433 DITOLYLGUANIDINE 1 -
CHEMBL567175 NALTRINDOLE 1 -
CHEMBL290543 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38874 DAMGO Ki = 1.49 nM 8.83
CHEMBL5187029 Ki = 56.0 nM 7.25
CHEMBL5207122 Ki = 1219.0 nM 5.91
CHEMBL5169420 Ki = 1770.0 nM 5.75
CHEMBL5201355 Ki = 2763.0 nM 5.56
CHEMBL5182253 Ki = 2905.0 nM 5.54
CHEMBL5186843 Ki = 3433.0 nM 5.46
CHEMBL5206034 Ki > 10000.0 nM -
CHEMBL5201238 Ki > 10000.0 nM -
CHEMBL54 HALOPERIDOL Ki - -
CHEMBL100116 PENTAZOCINE Ki - -
CHEMBL282433 DITOLYLGUANIDINE Ki - -
CHEMBL567175 NALTRINDOLE Ki - -
CHEMBL290543 Ki - -