Assay Detail
Binding
CHEMBL5117062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3 in human HEK293 cells transfected with JNK3-NanoLuc fusion vector measured after 1 hr by NanoBRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.75 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189795 | — | — | 1 | 6.43 |
| CHEMBL5191468 | — | — | 1 | 5.42 |
| CHEMBL5201911 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189795 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5191468 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5201911 | — | IC50 | = | 3920.0 | nM | 5.41 |