Compound Detail
CHEMBL5189795
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Basic Information
| ChEMBL ID | CHEMBL5189795 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCLOIQHNUARDSR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
437.9
MW (Da)
3.39
ALogP
7
HBA
4
HBD
94.2
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 8 CHEMBL2276 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 6.43 | 6.43 | 370.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 8 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of JNK1 (unknown origin) expressed in HEK293 cells assessed as target... | 37776574 |
| Mitogen-activated protein kinase 10 | IC50 | = | 370.0 | nM | 6.43 | Inhibition of JNK3 in human HEK293 cells transfected with JNK3-NanoLuc fusion ve... | 35764033 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35764033 | 10.1016/j.bmc.2022.116894 | Mitogen-activated protein kinase 10 | 1 |
| 37776574 | 10.1016/j.ejmech.2023.115779 | Mitogen-activated protein kinase 8 | 1 |
Data from ChEMBL 36 via Core Engine