Assay Detail
ADMET
CHEMBL5117063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6 (unknown origin) using EOMCC as a substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.40 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 8.73 |
| CHEMBL5191468 | — | — | 1 | 5.26 |
| CHEMBL5201911 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL5191468 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL5201911 | — | IC50 | = | 6240.0 | nM | 5.21 |