Assay Detail
ADMET
CHEMBL5117064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin) using BOMCC as a substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.26 |
| CHEMBL5191468 | — | — | 1 | 4.73 |
| CHEMBL5201911 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL5191468 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5201911 | — | IC50 | = | 20520.0 | nM | 4.69 |