Assay Detail
ADMET
CHEMBL5120633
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Inhibition of CYP3A4 (unknown origin) in presence of NADPH
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192063 | — | — | 1 | 6.40 |
| CHEMBL5173045 | — | — | 1 | 6.30 |
| CHEMBL5203646 | — | — | 1 | 6.16 |
| CHEMBL5192889 | — | — | 1 | 5.96 |
| CHEMBL5187209 | — | — | 1 | 5.57 |
| CHEMBL5188333 | — | — | 1 | 5.54 |
| CHEMBL5209379 | — | — | 1 | 5.52 |
| CHEMBL5205935 | — | — | 1 | 5.40 |
| CHEMBL5170161 | — | — | 1 | 5.10 |
| CHEMBL5184050 | — | — | 1 | - |
| CHEMBL4594441 | IFIDANCITINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192063 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5173045 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5203646 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5192889 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5187209 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5188333 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5209379 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5205935 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5170161 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5184050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4594441 | IFIDANCITINIB | IC50 | > | 10000.0 | nM | - |