Assay Detail
Binding
CHEMBL5125912
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Binding affinity to BRD4-T (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.65 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170488 | — | — | 1 | 9.54 |
| CHEMBL5206426 | — | — | 1 | 8.80 |
| CHEMBL5188470 | — | — | 1 | 8.77 |
| CHEMBL5184876 | — | — | 1 | 8.64 |
| CHEMBL5178175 | — | — | 1 | 8.55 |
| CHEMBL5201173 | — | — | 1 | 8.44 |
| CHEMBL5204093 | — | — | 1 | 8.32 |
| CHEMBL4760892 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170488 | — | Kd | = | 0.29 | nM | 9.54 |
| CHEMBL5206426 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL5188470 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL5184876 | — | Kd | = | 2.3 | nM | 8.64 |
| CHEMBL5178175 | — | Kd | = | 2.8 | nM | 8.55 |
| CHEMBL5201173 | — | Kd | = | 3.6 | nM | 8.44 |
| CHEMBL5204093 | — | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL4760892 | — | Kd | = | 6.7 | nM | 8.17 |