Assay Detail
Binding
CHEMBL5125914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BRDT-2 (250 to 382 residues) expressed in bacterial expression system by bromoscan assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain testis-specific protein (CHEMBL1795185) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.28 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178175 | — | — | 1 | 8.77 |
| CHEMBL5206426 | — | — | 1 | 8.66 |
| CHEMBL5188470 | — | — | 1 | 8.51 |
| CHEMBL5201173 | — | — | 1 | 8.46 |
| CHEMBL5170488 | — | — | 1 | 8.26 |
| CHEMBL5204093 | — | — | 1 | 8.08 |
| CHEMBL5184876 | — | — | 1 | 7.92 |
| CHEMBL4760892 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178175 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL5206426 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL5188470 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL5201173 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL5170488 | — | Kd | = | 5.5 | nM | 8.26 |
| CHEMBL5204093 | — | Kd | = | 8.4 | nM | 8.08 |
| CHEMBL5184876 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4760892 | — | Kd | = | 25.0 | nM | 7.60 |