Assay Detail
Functional
CHEMBL5126040
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Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus <i>Penicillium</i> sp. SCSIO 41512.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.17 | 4.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192236 | — | — | 1 | 4.26 |
| CHEMBL5181027 | — | — | 1 | 4.14 |
| CHEMBL4757140 | — | — | 1 | 4.12 |
| CHEMBL5189251 | — | — | 1 | - |
| CHEMBL5171831 | — | — | 1 | - |
| CHEMBL5192788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192236 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL5181027 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4757140 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL5189251 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5171831 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5192788 | — | IC50 | > | 80000.0 | nM | - |