Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5126775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
Fang Y, Li H, Ji B, Cheng K, Wu B, Li Z, Zheng C, Hua H, Li D.
Eur J Med Chem (2021) 210 : 113092 -113092
PubMed 33333398 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.69 8.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL450755 1 8.72
CHEMBL5207300 1 8.25
CHEMBL451147 RENIERAMYCIN M 1 8.10
CHEMBL468488 RENIERAMYCIN S 1 7.82
CHEMBL454372 RENIERAMYCIN R 1 7.64
CHEMBL503821 RENIERAMYCIN O 1 7.55
CHEMBL5169402 1 7.47
CHEMBL5191895 1 7.41
CHEMBL5175174 1 7.27
CHEMBL450708 RENIERAMYCIN Q 1 7.23
CHEMBL5208727 1 7.08
CHEMBL5176703 1 -
CHEMBL557545 CYANOJORUMYCIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL450755 IC50 = 1.9 nM 8.72
CHEMBL5207300 IC50 = 5.6 nM 8.25
CHEMBL451147 RENIERAMYCIN M IC50 = 7.9 nM 8.10
CHEMBL468488 RENIERAMYCIN S IC50 = 15.0 nM 7.82
CHEMBL454372 RENIERAMYCIN R IC50 = 23.0 nM 7.64
CHEMBL503821 RENIERAMYCIN O IC50 = 28.0 nM 7.55
CHEMBL5169402 IC50 = 34.0 nM 7.47
CHEMBL5191895 IC50 = 39.0 nM 7.41
CHEMBL5175174 IC50 = 54.0 nM 7.27
CHEMBL450708 RENIERAMYCIN Q IC50 = 59.0 nM 7.23
CHEMBL5208727 IC50 = 84.0 nM 7.08
CHEMBL5176703 IC50 > 1000.0 nM -
CHEMBL557545 CYANOJORUMYCIN IC50 < 0.38 nM -