Assay Detail
Functional
CHEMBL5126792
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Cytotoxicity against human DU-145 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.58 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554604 | JORUNNAMYCIN C | — | 1 | 9.49 |
| CHEMBL539920 | — | — | 1 | 9.31 |
| CHEMBL5201475 | — | — | 1 | 9.18 |
| CHEMBL5172965 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554604 | JORUNNAMYCIN C | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL539920 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5201475 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL5172965 | — | IC50 | = | 448.0 | nM | 6.35 |