Assay Detail
ADMET
CHEMBL5130159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoimager analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[<i>d</i>]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198576 | — | — | 1 | 8.70 |
| CHEMBL5177141 | — | — | 1 | 8.22 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 8.22 |
| CHEMBL5175710 | — | — | 1 | 8.10 |
| CHEMBL5184829 | — | — | 1 | 8.05 |
| CHEMBL5209512 | — | — | 1 | 7.92 |
| CHEMBL5186306 | — | — | 1 | 7.82 |
| CHEMBL5201480 | — | — | 1 | 7.77 |
| CHEMBL5174912 | — | — | 1 | 7.77 |
| CHEMBL5204043 | — | — | 1 | 7.66 |
| CHEMBL5203687 | — | — | 1 | 7.60 |
| CHEMBL5171157 | — | — | 1 | 7.51 |
| CHEMBL5204850 | — | — | 1 | 7.50 |
| CHEMBL5175708 | — | — | 1 | 7.46 |
| CHEMBL5195761 | — | — | 1 | 7.43 |
| CHEMBL5196347 | — | — | 1 | 7.34 |
| CHEMBL5186765 | — | — | 1 | 7.34 |
| CHEMBL5175784 | — | — | 1 | 7.31 |
| CHEMBL5171873 | — | — | 1 | 7.24 |
| CHEMBL5199220 | — | — | 1 | 7.19 |
| CHEMBL5197879 | — | — | 1 | 7.10 |
| CHEMBL5197102 | — | — | 1 | 7.08 |
| CHEMBL5185819 | — | — | 1 | 7.07 |
| CHEMBL5202317 | — | — | 1 | 7.02 |
| CHEMBL5202486 | — | — | 1 | 7.01 |
| CHEMBL5183554 | — | — | 1 | 6.97 |
| CHEMBL5204984 | — | — | 1 | 6.95 |
| CHEMBL5189860 | — | — | 1 | 6.94 |
| CHEMBL5192747 | — | — | 1 | 6.89 |
| CHEMBL5171092 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198576 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5177141 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5175710 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5184829 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5209512 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5186306 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5201480 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5174912 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5204043 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5203687 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5171157 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5204850 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5175708 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5195761 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5196347 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5186765 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5175784 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5171873 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5199220 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5197879 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5197102 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5185819 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5202317 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5202486 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5183554 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5204984 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5189860 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5192747 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5171092 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5189922 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL5175297 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5175134 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5196053 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL5203488 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL5173465 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5195876 | — | IC50 | = | 189.0 | nM | 6.72 |