Assay Detail
Binding
CHEMBL5131019
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Inhibition of human myc-His6-tagged zDHHC20 expressed in HEK293T cells using 5-FAM-GTQGCMGLPCVVM-COOH as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for 2 hrs in presence of palmitoyl-CoA by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.37 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201039 | — | — | 1 | 5.87 |
| CHEMBL5186346 | — | — | 1 | 5.71 |
| CHEMBL5199102 | — | — | 1 | 5.54 |
| CHEMBL5205503 | — | — | 1 | 5.46 |
| CHEMBL5191244 | — | — | 1 | 5.46 |
| CHEMBL118417 | — | — | 1 | 5.26 |
| CHEMBL5181387 | — | — | 1 | 5.01 |
| CHEMBL5171728 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201039 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5186346 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5199102 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL5205503 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL5191244 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL118417 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL5181387 | — | IC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL5171728 | — | IC50 | = | 21400.0 | nM | 4.67 |