Assay Detail
Functional
CHEMBL5133047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human CysLT1 expressed in CHO cells assessed as inhibition of LTD4 induced cytosolic Calcium ion mobilization measured after 75 mins by Fluo4 dye based fluorimetric microplate reader assay relative to control
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.55 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | — | 1 | 5.96 |
| CHEMBL5174405 | — | — | 1 | 5.92 |
| CHEMBL5181326 | — | — | 1 | 5.68 |
| CHEMBL5169385 | — | — | 1 | 5.55 |
| CHEMBL5173307 | — | — | 1 | 5.41 |
| CHEMBL5189181 | — | — | 1 | 5.29 |
| CHEMBL5192002 | — | — | 1 | 5.02 |
| CHEMBL5205902 | — | — | 1 | - |
| CHEMBL5202995 | — | — | 1 | - |
| CHEMBL5193617 | — | — | 1 | - |
| CHEMBL5185938 | — | — | 1 | - |
| CHEMBL5177797 | — | — | 1 | - |
| CHEMBL5189686 | — | — | 1 | - |
| CHEMBL18775 | — | — | 1 | - |
| CHEMBL5173976 | — | — | 1 | - |
| CHEMBL5172427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5174405 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5181326 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5169385 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5173307 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5189181 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL5192002 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL5205902 | — | IC50 | - | — | - | |
| CHEMBL5202995 | — | IC50 | - | — | - | |
| CHEMBL5193617 | — | IC50 | - | — | - | |
| CHEMBL5185938 | — | IC50 | - | — | - | |
| CHEMBL5177797 | — | IC50 | - | — | - | |
| CHEMBL5189686 | — | IC50 | - | — | - | |
| CHEMBL18775 | — | IC50 | - | — | - | |
| CHEMBL5173976 | — | IC50 | - | — | - | |
| CHEMBL5172427 | — | IC50 | - | — | - |