Compound Detail
CHEMBL5173307
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Basic Information
| ChEMBL ID | CHEMBL5173307 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | INKCQRGAPBDVIZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
293.3
MW (Da)
3.60
ALogP
4
HBA
0
HBD
48.4
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 CHEMBL1798 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | IC50 | = | 3900.0 | nM | 5.41 | Antagonist activity against human CysLT1 expressed in CHO cells assessed as inhi... | 34767347 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34767347 | 10.1021/acs.jmedchem.1c01078 | Cysteinyl leukotriene receptor 1 | 2 |
| 34767347 | 10.1021/acs.jmedchem.1c01078 | G-protein coupled bile acid receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine