Assay Detail
Binding
CHEMBL5134828
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Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.14 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182936 | — | — | 1 | 6.92 |
| CHEMBL250870 | — | — | 1 | 6.68 |
| CHEMBL225519 | — | — | 1 | 6.52 |
| CHEMBL250871 | — | — | 1 | 6.36 |
| CHEMBL5175087 | — | — | 1 | 6.28 |
| CHEMBL5202568 | — | — | 1 | 5.89 |
| CHEMBL5187643 | — | — | 1 | 5.74 |
| CHEMBL5170263 | — | — | 1 | 5.52 |
| CHEMBL252724 | — | — | 1 | 5.35 |
| CHEMBL255031 | — | — | 1 | - |
| CHEMBL5208324 | — | — | 1 | - |
| CHEMBL254392 | — | — | 1 | - |
| CHEMBL5182853 | — | — | 1 | - |
| CHEMBL5176291 | — | — | 1 | - |
| CHEMBL5187274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182936 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL250870 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL225519 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL250871 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5175087 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5202568 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5187643 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5170263 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL252724 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL255031 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5208324 | — | IC50 | - | — | - | |
| CHEMBL254392 | — | IC50 | - | — | - | |
| CHEMBL5182853 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5176291 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5187274 | — | IC50 | > | 5000.0 | nM | - |