Compound Detail
CHEMBL5202568
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5202568 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQYKIBPUNQVZRF-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
212.2
MW (Da)
2.60
ALogP
2
HBA
1
HBD
45.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Ki 2 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase N2 CHEMBL3032 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Serine/threonine-protein kinase N2 CHEMBL3032 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Serine/threonine-protein kinase N1 CHEMBL3384 | Ki | 6.19 | 6.19 | 650.0 | 1 |
| Serine/threonine-protein kinase N1 CHEMBL3384 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase N2 | Ki | = | 30.0 | nM | 7.52 | Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assay d... | 35104640 |
| Serine/threonine-protein kinase N2 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assay | 35104640 |
| Serine/threonine-protein kinase N1 | Ki | = | 650.0 | nM | 6.19 | Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay d... | 35104640 |
| Serine/threonine-protein kinase N1 | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay | 35104640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35104640 | 10.1016/j.bmcl.2022.128588 | Serine/threonine-protein kinase N2 | 2 |
| 35104640 | 10.1016/j.bmcl.2022.128588 | Serine/threonine-protein kinase N1 | 2 |
| 35104640 | 10.1016/j.bmcl.2022.128588 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine