Assay Detail
Binding
CHEMBL5136476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT transfected in HEK cells using APP+ as fluorescent substrate preincubated for 1 hr followed by substrate addition and measured after 30 mins by fluorescence plate reader assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ibogaine and Their Analogs as Therapeutics for Neurological and Psychiatric Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.53 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188930 | — | — | 1 | 8.29 |
| CHEMBL5175119 | — | — | 1 | 7.58 |
| CHEMBL5207764 | — | — | 1 | 7.23 |
| CHEMBL5201219 | — | — | 1 | 7.10 |
| CHEMBL5202868 | — | — | 1 | 6.55 |
| CHEMBL5184088 | — | — | 1 | 6.48 |
| CHEMBL1215855 | — | — | 1 | 6.30 |
| CHEMBL5188726 | — | — | 1 | 6.17 |
| CHEMBL5180373 | — | — | 1 | 6.04 |
| CHEMBL5171433 | — | — | 1 | 5.82 |
| CHEMBL5176306 | — | — | 1 | 5.72 |
| CHEMBL5207655 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188930 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5175119 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5207764 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5201219 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5202868 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5184088 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1215855 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5188726 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5180373 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5171433 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5176306 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5207655 | — | IC50 | = | 9000.0 | nM | 5.05 |