Assay Detail
Functional
CHEMBL5137257
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Antiparasitic activity against bloodstream form of tbat1-/- deficient Trypanosoma brucei brucei measured after 48 hrs by alamar blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.23 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 6.75 |
| CHEMBL3824266 | — | — | 1 | 6.26 |
| CHEMBL3822898 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3824266 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3822898 | — | EC50 | = | 2100.0 | nM | 5.68 |