Assay Detail
Binding
CHEMBL5137602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SARS CoV-2 PL protease incubated for 60 mins by fluorescence based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922662 | — | — | 1 | 6.62 |
| CHEMBL3983492 | — | — | 1 | 6.58 |
| CHEMBL3912164 | — | — | 1 | 6.58 |
| CHEMBL3928799 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922662 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3983492 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3912164 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3928799 | — | IC50 | = | 34000.0 | nM | 4.47 |