Compound Detail
CHEMBL3928799
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3928799 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KWHUYBHCJSYTIT-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
582.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Replicase polyprotein 1ab CHEMBL4523582 | IC50 | 6.47 | 5.47 | 339.0 | 2 |
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 5.26 | 5.26 | 5440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Replicase polyprotein 1ab | IC50 | = | 339.0 | nM | 6.47 | Inhibition of SARS-CoV-2 papain-like protease preincubated for 60 mins | 35620927 |
| Methionine aminopeptidase 2 | IC50 | = | 5440.0 | nM | 5.26 | Non-covalent/mixed type inhibition of recombinant human MetAP2 using Met-AMC as ... | 27692546 |
| Replicase polyprotein 1ab | IC50 | = | 34000.0 | nM | 4.47 | Inhibition of recombinant SARS CoV-2 PL protease incubated for 60 mins by fluore... | 33186044 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Aminopeptidase N | 2 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Leucine aminopeptidase | 1 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Methionine aminopeptidase 2 | 1 |
| 33186044 | 10.1021/acs.jmedchem.0c01140 | Replicase polyprotein 1ab | 1 |
| 35620927 | 10.1021/acs.jmedchem.2c00303 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine