Assay Detail
Binding
CHEMBL5139920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 papain-like protease preincubated for 60 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.39 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922662 | — | — | 1 | 6.63 |
| CHEMBL3983492 | — | — | 1 | 6.59 |
| CHEMBL3912164 | — | — | 1 | 6.58 |
| CHEMBL3928799 | — | — | 1 | 6.47 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922662 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3983492 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL3912164 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL3928799 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL51085 | EBSELEN | IC50 | = | 2020.0 | nM | 5.70 |