Assay Detail
Binding
CHEMBL5138014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR in human A-431 cell membrane vesicles using phospholipase C-gamma-1 as substrate incubated for 10 mins by scintillation counter method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Subcellular | Membrane vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
How the structural properties of the indole derivatives are important in kinase targeted drug design?: A case study on tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153206 | — | — | 1 | 8.92 |
| CHEMBL423224 | — | — | 1 | 7.51 |
| CHEMBL5198809 | — | — | 1 | 7.14 |
| CHEMBL5173075 | — | — | 1 | 6.34 |
| CHEMBL5195327 | — | — | 1 | - |
| CHEMBL5179320 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153206 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL423224 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5198809 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5173075 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5195327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5179320 | — | IC50 | > | 10000.0 | nM | - |