Compound Detail
CHEMBL5198809
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Basic Information
| ChEMBL ID | CHEMBL5198809 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MQJJIOLMGNHHTC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
339.2
MW (Da)
4.62
ALogP
3
HBA
2
HBD
53.6
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 72.0 | nM | 7.14 | Inhibition of EGFR in human A-431 cell membrane vesicles using phospholipase C-g... | 34864496 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34864496 | 10.1016/j.bmc.2021.116534 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine