Assay Detail
Binding
CHEMBL5139921
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) using Ac-LRGG-ACC as substrate preincubated for 10 mins by spectrofluorometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.92 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199343 | — | — | 1 | 6.24 |
| CHEMBL5206009 | — | — | 1 | 6.00 |
| CHEMBL5177233 | — | — | 1 | 5.98 |
| CHEMBL5194538 | — | — | 1 | 5.90 |
| CHEMBL5202141 | — | — | 1 | 5.89 |
| CHEMBL5195364 | — | — | 1 | 5.72 |
| CHEMBL5193976 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199343 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL5206009 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5177233 | — | IC50 | = | 1038.0 | nM | 5.98 |
| CHEMBL5194538 | — | IC50 | = | 1255.0 | nM | 5.90 |
| CHEMBL5202141 | — | IC50 | = | 1288.0 | nM | 5.89 |
| CHEMBL5195364 | — | IC50 | = | 1885.0 | nM | 5.72 |
| CHEMBL5193976 | — | IC50 | = | 2067.0 | nM | 5.68 |