Assay Detail
Binding
CHEMBL5139922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using QS1 as substrate incubated for 2 mins by spectrofluorometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.50 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193976 | — | — | 1 | 7.82 |
| CHEMBL5194538 | — | — | 1 | 7.59 |
| CHEMBL5202141 | — | — | 1 | 7.56 |
| CHEMBL5195364 | — | — | 1 | 7.55 |
| CHEMBL5177233 | — | — | 1 | 7.42 |
| CHEMBL5199343 | — | — | 1 | 7.30 |
| CHEMBL5206009 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193976 | — | IC50 | = | 15.24 | nM | 7.82 |
| CHEMBL5194538 | — | IC50 | = | 25.69 | nM | 7.59 |
| CHEMBL5202141 | — | IC50 | = | 27.37 | nM | 7.56 |
| CHEMBL5195364 | — | IC50 | = | 27.95 | nM | 7.55 |
| CHEMBL5177233 | — | IC50 | = | 37.81 | nM | 7.42 |
| CHEMBL5199343 | — | IC50 | = | 49.55 | nM | 7.30 |
| CHEMBL5206009 | — | IC50 | = | 52.5 | nM | 7.28 |