Assay Detail
Functional
CHEMBL5139985
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Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque reduction assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.54 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205701 | — | — | 1 | 6.89 |
| CHEMBL5190021 | — | — | 1 | 6.85 |
| CHEMBL4454397 | — | — | 1 | 6.80 |
| CHEMBL5169723 | — | — | 1 | 6.80 |
| CHEMBL3343458 | — | — | 1 | 6.66 |
| CHEMBL5173260 | — | — | 1 | 6.66 |
| CHEMBL2386126 | — | — | 1 | 6.64 |
| CHEMBL5200310 | — | — | 1 | 6.58 |
| CHEMBL5192335 | — | — | 1 | 6.57 |
| CHEMBL3343444 | — | — | 1 | 6.57 |
| CHEMBL5180128 | — | — | 1 | 6.55 |
| CHEMBL5185946 | — | — | 1 | 6.54 |
| CHEMBL5187428 | — | — | 1 | 6.51 |
| CHEMBL5193508 | — | — | 1 | 6.51 |
| CHEMBL3343456 | — | — | 1 | 6.41 |
| CHEMBL5199084 | — | — | 1 | 6.41 |
| CHEMBL5204943 | — | — | 1 | 6.39 |
| CHEMBL1413 | CICLOPIROX | 4.0 | 1 | 6.30 |
| CHEMBL4576686 | — | — | 1 | 6.26 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205701 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5190021 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4454397 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5169723 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3343458 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5173260 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2386126 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5200310 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5192335 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3343444 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5180128 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5185946 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5187428 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5193508 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3343456 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5199084 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5204943 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1413 | CICLOPIROX | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4576686 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1440.0 | nM | 5.84 |