Assay Detail
Binding
CHEMBL5140915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Androgen receptor (unknown origin)
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Strategies to Target the Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.31 | 8.70 |
| Ki | 3 | 7.82 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229861 | — | — | 1 | 9.05 |
| CHEMBL246006 | — | — | 1 | 8.70 |
| CHEMBL4088914 | — | — | 1 | 8.44 |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 1 | 7.96 |
| CHEMBL5209205 | — | — | 1 | 7.90 |
| CHEMBL5196915 | — | — | 1 | 7.00 |
| CHEMBL221174 | — | — | 1 | 6.85 |
| CHEMBL124881 | (S)-BICALUTAMIDE | — | 1 | 6.44 |
| CHEMBL1099086 | — | — | 1 | 6.36 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 5.89 |
| CHEMBL2346967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229861 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL246006 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4088914 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL63560 | (R)-BICALUTAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5209205 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5196915 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL221174 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL124881 | (S)-BICALUTAMIDE | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL1099086 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2346967 | — | IC50 | > | 79432.82 | nM | - |