Compound Detail
CHEMBL5209205
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Basic Information
| ChEMBL ID | CHEMBL5209205 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCCGHQZCKDIQDC-FQEVSTJZSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
2.81
ALogP
4
HBA
1
HBD
73.6
PSA (Ų)
0.90
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.6
IC50 1 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | EC50 | 8.6 | 8.6 | 2.5 | 1 |
| Androgen receptor CHEMBL1871 | IC50 | 7.9 | 7.9 | 12.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | EC50 | = | 2.5 | nM | 8.6 | Agonist activity at Androgen receptor (unknown origin) measured by androgen resp... | 35786895 |
| Androgen receptor | IC50 | = | 12.7 | nM | 7.9 | Binding affinity to Androgen receptor (unknown origin) | 35786895 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35786895 | 10.1021/acs.jmedchem.2c00716 | Androgen receptor | 2 |
Data from ChEMBL 36 via Core Engine