Assay Detail
Binding
CHEMBL5141063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAT2A in human NCI-H520 cells transfected with MAT2A empty vector assessed as inhibition of S-adenosyl methionine production measured after 6 hrs by Rapid Fire Mass Spectrometry analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H520 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
S-adenosylmethionine synthase isoform type-2 (CHEMBL3313835) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overview of Methionine Adenosyltransferase 2A (MAT2A) as an Anticancer Target: Structure, Function, and Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.92 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337420 | — | — | 1 | 5.92 |
| CHEMBL295830 | CYCLOLEUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337420 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL295830 | CYCLOLEUCINE | IC50 | = | 5600000.0 | nM | - |